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1

Structural Insights into RNA-Dependent Ring Closure and ATPase Activation by the Rho Termination Factor

Emmanuel Skordalakes, James M. Berger

Journal:

Year:

2006

Language:

english

File:

PDF, 1.55 MB

english, 2006

2

Rhodium(I)-catalysed hydroboration of 1-halo-1-alkenes

Said Elgendy, Geeta Patel, Vijay V. Kakkar, Goran Claeson, Donovan Green, Emmanuel Skordalakes, Jehan A. Baban, John Deadman

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 112 KB

english, 1994

3

Design of a novel class of bifunctional thrombin inhibitors, synthesised by the first application of peptide boronates in solid phase chemistry

Said Elgendy, Geeta Patel, Donovan Green, Christopher A. Goodwin, Michael F. Scully, Wahid Husman, Emmanuel Skordalakes, Vijay V. Kakkar, John J. Deadman

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 221 KB

english, 1997

4

The facile synthesis of O,O-Dialkyl α-halobenzylphosphonates from O,O-Dialkyl α-hydroxybenzylphosphonates

Donovan Green, Said Elgendy, Geeta Patel, Jehan A. Baban, Emmanuel Skordalakes, Wahid Husman, Vijay V. Kakkar, John Deadman

Journal:

Year:

1996

Language:

english

File:

PDF, 656 KB

english, 1996

5

Structure of the Tribolium castaneum telomerase catalytic subunit TERT

Gillis, Andrew J., Schuller, Anthony P., Skordalakes, Emmanuel

Journal:

Year:

2008

Language:

english

File:

PDF, 609 KB

english, 2008

6

Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA

Mitchell, Meghan, Gillis, Andrew, Futahashi, Mizuko, Fujiwara, Haruhiko, Skordalakes, Emmanuel

Journal:

Nature Structural and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.11 MB

english, 2010

7

ChemInform Abstract: The Facile Synthesis of O,O-Dialkyl α-Halobenzylphosphonates from O,O-Dialkyl α-Hydroxybenzylphosphonates.

D. GREEN, S. ELGENDY, G. PATEL, J. A. BABAN, E. SKORDALAKES, W. HUSMAN, V. V. KAKKAR, J. DEADMAN

Journal:

Year:

1996

File:

PDF, 31 KB

1996

8

Structure and Function of the Conserved Core of Histone Deposition Protein Asf1

Sally M Daganzo, Jan P Erzberger, Wendy M Lam, Emmanuel Skordalakes, Rugang Zhang, Alexa A Franco, Steven J Brill, Peter D Adams, James M Berger, Paul D Kaufman

Journal:

Current Biology

Year:

2003

Language:

english

File:

PDF, 567 KB

english, 2003

9

Telomerase structure function

Mark Mason, Anthony Schuller, Emmanuel Skordalakes

Journal:

Current Opinion in Structural Biology

Year:

2011

Language:

english

File:

PDF, 899 KB

english, 2011

10

Structural Mechanism of Inhibition of the Rho Transcription Termination Factor by the Antibiotic Bicyclomycin

Emmanuel Skordalakes, Andrew P. Brogan, Boon Saeng Park, Harold Kohn, James M. Berger

Journal:

Year:

2005

Language:

english

File:

PDF, 554 KB

english, 2005

11

Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding

Susan Rouda, Emmanuel Skordalakes

Journal:

Year:

2007

Language:

english

File:

PDF, 1.35 MB

english, 2007

12

Inhibition of human α-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate

Emmanuel Skordalakes, Guy G Dodson, Donovan St Clair Green, Christopher A Goodwin, Michael F Scully, Harry R Hudson, Vijay V Kakkar, John J Deadman

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 334 KB

english, 2001

13

Comparison of Proteolytic Susceptibility in Phosphoglycerate Kinases from Yeast and E. coli: Modulation of Conformational Ensembles Without Altering Structure or Stability

Tracy A. Young, Emmanuel Skordalakes, Susan Marqusee

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 712 KB

english, 2007

14

Structure of the Rho Transcription Terminator: Mechanism of mRNA Recognition and Helicase Loading

Emmanuel Skordalakes, James M Berger

Journal:

Year:

2003

Language:

english

File:

PDF, 575 KB

english, 2003

15

Telomerase and the benefits of healthy living

Emmanuel Skordalakes

Journal:

The Lancet Oncology

Year:

2008

Language:

english

File:

PDF, 285 KB

english, 2008

16

In vitro Reconstitution of the Active T. castaneum Telomerase

Schuller, Anthony P., Harkisheimer, Michael J., Skordalakes, Emmanuel

Journal:

Journal of Visualized Experiments

Year:

2011

Language:

english

File:

PDF, 62 KB

english, 2011

17

THE FACILE SYNTHESIS OF 1-AMINOPHOSPHONATES FROM 1-NITROPHOSPHONATE PRECURSORS

Green, Donovan, Elgendy, Said, Patel, Geeta, Baban, Jehan A., Skordalakes, Emmanuel, Husman, Wahid, Kakkar, Vijay V., Deadman, John

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1996

Language:

english

File:

PDF, 232 KB

english, 1996

18

Structure of the Human Telomeric Stn1-Ten1 Capping Complex

Bryan, Christopher, Rice, Cory, Harkisheimer, Michael, Schultz, David C., Skordalakes, Emmanuel, Lustig, Arthur J.

Journal:

Year:

2013

Language:

english

File:

PDF, 3.02 MB

english, 2013

19

Characterization of a Class of Peptide Boronates with Neutral P1 Side Chains as Highly Selective Inhibitors of Thrombin

Deadman, John J., Elgendy, Said, Goodwin, Christopher A., Green, Donovan, Baban, Jehan A., Patel, Geeta, Skordalakes, Emmanuel, Chino, Naoyoshi, Claeson, Goran

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.49 MB

english, 1995

20

A Motif in the Vertebrate Telomerase N-Terminal Linker of TERT Contributes to RNA Binding and Telomerase Activity and Processivity

Harkisheimer, Michael, Mason, Mark, Shuvaeva, Elena, Skordalakes, Emmanuel

Journal:

Year:

2013

Language:

english

File:

PDF, 2.54 MB

english, 2013

21

Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere Maintenance

Mason, Mark, Wanat, Jennifer J., Harper, Sandy, Schultz, David C., Speicher, David W., Johnson, F. Brad, Skordalakes, Emmanuel

Journal:

Year:

2013

Language:

english

File:

PDF, 1.88 MB

english, 2013

22

Bifunctional Peptide Boronate Inhibitors of Thrombin: Crystallographic Analysis of Inhibition Enhanced by Linkage to an Exosite 1 Binding Peptide

Skordalakes, Emmanuel, Elgendy, Said, Goodwin, Christopher A., Green, Donovan, Scully, Michael F., Kakkar, Vijay V., Freyssinet, Jean-Marie, Dodson, Guy, Deadman, John J.

Journal:

Year:

1998

Language:

english

File:

PDF, 131 KB

english, 1998

23

Crystallographic Structures of Human α-Thrombin Complexed to Peptide Boronic Acids Lacking a Positive Charge at P1. Evidence of Novel Interactions

Skordalakes, Emmanuel, Tyrell, Richard, Elgendy, Said, Goodwin, Christopher A., Green, Donovan, Dodson, Guy, Scully, Michael F., Freyssinet, Jean-Marie H., Kakkar, Vijay V., Deadman, John J.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 100 KB

english, 1997

24

X-Ray Crystallographic Analyses of Human α-Thrombin Complexed to Peptidyl Aminophosphonates: Evidence of a Binding Mechanism

Green, Donovan, Skordalakes, Emmanuel, Scully, Michael F., Goodwin, Christopher, Merette, Sandrine, Burd, Andrew, Kakkar, Vijay V., Deadman, John

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1999

Language:

english

File:

PDF, 222 KB

english, 1999

25

Substrate Related O,O -Dialkyldipeptidylaminophosphonates, A New Type of Thrombin Inhibitor

Green, Donovan, Patel, Geeta, Elgendy, Said, Baban, Jehan A., Skordalakes, Emmanuel, Husman, Wahid, Goodwin, Christopher A., Scully, Michael F., Kakkar, Vijay V., Deadman, John

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1996

Language:

english

File:

PDF, 219 KB

english, 1996

26

Telomerase structure paves the way for new cancer therapies

Skordalakes, Emmanuel

Journal:

Future Oncology

Year:

2009

Language:

english

File:

PDF, 547 KB

english, 2009

27

THE SYNTHESIS AND FAB MASS ANALYSIS OF O,O -DIALKYL 1-BENZYLAMINOBENZYLPHOSPHONATES, PRECURSORS OF IMPORTANT STRUCTURAL UNITS IN ANTI-THROMBOTIC TRIPEPTIDES

Green, Donovan, Elgendy, Said, Patel, Geeta, Skordalakes, Emmanuel, Husman, Wahid, Kakkar, Vijay V., Deadman, John

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1996

Language:

english

File:

PDF, 1.00 MB

english, 1996

28

A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion

Hansen, C. L., Skordalakes, E., Berger, J. M., Quake, S. R.

Journal:

Proceedings of the National Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 376 KB

english, 2002

29

Single Cell Analysis of RNA-mediated Histone H3.3 Recruitment to a Cytomegalovirus Promoter-regulated Transcription Site

Newhart, A., Rafalska-Metcalf, I. U., Yang, T., Joo, L. M., Powers, S. L., Kossenkov, A. V., Lopez-Jones, M., Singer, R. H., Showe, L. C., Skordalakes, E., Janicki, S. M.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 4.87 MB

english, 2013

30

Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation

McCray, B. A., Skordalakes, E., Taylor, J. P.

Journal:

Human Molecular Genetics

Year:

2010

Language:

english

File:

PDF, 667 KB

english, 2010

31

Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation

Wang, A. Y., Schulze, J. M., Skordalakes, E., Gin, J. W., Berger, J. M., Rine, J., Kobor, M. S.

Journal:

Proceedings of the National Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 1.75 MB

english, 2009

32

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme

Carlson, B. L., Ballister, E. R., Skordalakes, E., King, D. S., Breidenbach, M. A., Gilmore, S. A., Berger, J. M., Bertozzi, C. R.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 1.07 MB

english, 2008

33

Cdc13 N-Terminal Dimerization, DNA Binding, and Telomere Length Regulation

Mitchell, M. T., Smith, J. S., Mason, M., Harper, S., Speicher, D. W., Johnson, F. B., Skordalakes, E.

Journal:

Molecular and Cellular Biology

Year:

2010

Language:

english

File:

PDF, 1.73 MB

english, 2010

34

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

Panneer Selvam, S., De Palma, R. M., Oaks, J. J., Oleinik, N., Peterson, Y. K., Stahelin, R. V., Skordalakes, E., Ponnusamy, S., Garrett-Mayer, E., Smith, C. D., Ogretmen, B.

Journal:

Science Signaling

Year:

2015

Language:

english

File:

PDF, 1.42 MB

english, 2015

35

Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes

Iwasaki, Osamu, Tanizawa, Hideki, Kim, Kyoung-Dong, Yokoyama, Yuhki, Corcoran, Christopher J., Tanaka, Atsunari, Skordalakes, Emmanuel, Showe, Louise C., Noma, Ken-ichi

Journal:

Year:

2015

Language:

english

File:

PDF, 3.98 MB

english, 2015

36

Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532

Bryan, Christopher, Rice, Cory, Hoffman, Hunter, Harkisheimer, Michael, Sweeny, Melanie, Skordalakes, Emmanuel

Journal:

Year:

2015

Language:

english

File:

PDF, 2.46 MB

english, 2015

37

The Telomere Binding Protein Cdc13 and the Single-Stranded DNA Binding Protein RPA Protect Telomeric DNA from Resection by Exonucleases

Greetham, Matthew, Skordalakes, Emmanuel, Lydall, David, Connolly, Bernard A.

Journal:

Journal of Molecular Biology

Year:

2015

Language:

english

File:

PDF, 747 KB

english, 2015

38

Structure and function of the telomeric CST complex

Rice, Cory, Skordalakes, Emmanuel

Journal:

Computational and Structural Biotechnology Journal

Year:

2016

Language:

english

File:

PDF, 1.00 MB

english, 2016

39

SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase

Zhu, Hengrui, Ren, Shancheng, Bitler, Benjamin G., Aird, Katherine M., Tu, Zhigang, Skordalakes, Emmanuel, Zhu, Yasheng, Yan, Jun, Sun, Yinghao, Zhang, Rugang

Journal:

Year:

2015

Language:

english

File:

PDF, 3.24 MB

english, 2015

40

SUBSTRATE RELATED O,O-DIALKYLDIPEPTIDYLY ψ CARBOXYBENZYLPHOSPHONATES, A NEW TYPE OF THROMBIN INHIBITOR

Green, Donovan, Elgendy, Said, Patel, Geeta, Skordalakes, Emmanuel, Goodwin, Christopher A., Scully, Micheal F., Kakkar, Vijay V., Deadman, John J.

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

2000

Language:

english

File:

PDF, 399 KB

english, 2000

41

Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes

Hoffman, Hunter, Rice, Cory, Skordalakes, Emmanuel

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 2.29 MB

english, 2017

42

Structural and functional analysis of the human POT1-TPP1 telomeric complex

Rice, Cory, Shastrula, Prashanth Krishna, Kossenkov, Andrew V., Hills, Robert, Baird, Duncan M., Showe, Louise C., Doukov, Tzanko, Janicki, Susan, Skordalakes, Emmanuel

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 3.86 MB

english, 2017

43

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

Sakurai, Masayuki, Shiromoto, Yusuke, Ota, Hiromitsu, Song, Chunzi, Kossenkov, Andrew V, Wickramasinghe, Jayamanna, Showe, Louise C, Skordalakes, Emmanuel, Tang, Hsin-Yao, Speicher, David W, Nishikura

Journal:

Nature Structural and Molecular Biology

Year:

2017

Language:

english

File:

PDF, 4.75 MB

english, 2017

44

Telomerase structure function

Skordalakes, E.

Journal:

Acta Crystallographica Section A Foundations of Crystallography

Year:

2011

Language:

english

File:

PDF, 356 KB

english, 2011

45

Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes

Shastrula, Prashanth K, Rice, Cory T, Wang, Zhuo, Lieberman, Paul M, Skordalakes, Emmanuel

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 5.08 MB

english, 2018

46

A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity

Hernandez-Sanchez, Wilnelly, Huang, Wei, Plucinsky, Brian, Garcia-Vazquez, Nelson, Robinson, Nathaniel J., Schiemann, William P., Berdis, Anthony J., Skordalakes, Emmanuel, Taylor, Derek J., Smogorzew

Journal:

Year:

2019

Language:

english

File:

PDF, 6.69 MB

english, 2019

47

Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncology

Di Sante, Gabriele, Pagé, Jessica, Jiao, Xuanmao, Nawab, Omar, Cristofanilli, Massimo, Skordalakes, Emmanuel, Pestell, Richard G

Journal:

Expert Review of Anticancer Therapy

Year:

2019

File:

PDF, 2.84 MB

2019

48

Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

Ren, Wenqing, Medeiros, Nicole, Warneford-Thomson, Robert, Wulfridge, Phillip, Yan, Qingqing, Bian, Joyce, Sidoli, Simone, Garcia, Benjamin A., Skordalakes, Emmanuel, Joyce, Eric, Bonasio, Roberto, Sa

Journal:

Nature Communications

Year:

2020

File:

PDF, 2.25 MB

2020

49

POT1-TPP1 telomere length regulation and disease

Aramburu, Tomas, Plucinsky, Sarah, Skordalakes, Emmanuel

Journal:

Computational and Structural Biotechnology Journal

Year:

2020

File:

PDF, 1.62 MB

2020

50

Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation

Chen, Ke, Jiao, Xuanmao, Di Rocco, Agnese, Shen, Duanwen, Xu, Shaohua, Ertel, Adam, Yu, Zuoren, Di Sante, Gabriele, Wang, Min, Li, Zhiping, Pestell, Timothy G., Casimiro, Mathew C., Skordalakes, Emman

Journal:

Year:

2020

File:

PDF, 827 KB

2020

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